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Multidisciplinary NAFLD approach improves liver-related, cardiovascular risk factors

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International Liver Congress

August 27, 2020

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Mantovani A, et al. Abstract AS160. Presented at: The Digital International Liver Congress. Aug. 27-29, 2020.

Mantovani reports no relevant financial disclosures.

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A multidisciplinary nonalcoholic fatty liver disease approach effectively improved liver-related and cardiovascular risk factors, according to research presented at The Digital International Liver Congress.

Anna Mantovani, from Royal Free Hospital and UCL Institute for Liver and Digestive Health in London, United Kingdom, and colleagues prospectively collected data of 273 patients referred to a multidisciplinary NAFLD clinic from hepatological consultation, cardiovascular risk assessment and dietetic counseling. They followed patients for a median of 18 months.

The data showed a baseline prevalence of obesity of 60%, 67% for hypertension and 60% for diabetes. Additionally, 13.2% of patients had a positive history of cardiovascular events. Dyslipidemia management was suboptimal in 64 patients at baseline and 57 patients with diabetes and 36 patients with hypertension required treatment modification.

During follow up, researchers saw improvements in alanine aminotransferase (P = .013), aspartate aminotransferase (P = .013), systolic and diastolic blood pressure (P = .002 and P = .014 respectively), total cholesterol (P < .001) and glycated hemoglobin in patients with diabetes (70.2-62.5 mmol/mol; P = .04).

According to Mantovani, 142 patients achieved weight loss during the follow-up. Study results also showed a decrease in the total number of patients with a QRISK3score of 10% or greater from 156 to 97.

“For both primary and secondary care, we reached our ideal target in 80% of patients,” she said.

“A strong collaboration between primary and secondary care is essential to implement and maintain these improvements in the long term.”

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